Table 2.
Distributions of Genotype and Allele Frequencies of SNPs rs2074192, rs2106809, rs1799752, rs4762, rs699 and rs5186 Observed in Asymptomatic and Symptomatic Patients
| Asymptomatic (n=50) | Symptomatic (n=54) | |||
|---|---|---|---|---|
|
rs2074192 ACE2 (Xp22.2) c.*1860-449C>T intron variant |
Genotypes (%) | C/C | 28 (56) | 27 (50) |
| C/T | 21 (42) | 7 (13) | ||
| T/T | 1 (2) | 20 (37) | ||
| Alleles (%) | C | 77 (77) | 61 (56) | |
| T | 23 (23) | 47 (44) | ||
| HW (p) females | 0.37 | 0.0088 | ||
| HW (p) males | 0.13 | <0.0001 | ||
|
rs2106809 ACE2 (Xp22.2) c.*264+788T>C intron variant |
Genotypes (%) | A/A | 38 (76) | 40 (74) |
| A/G | 4 (8) | 3 (6) | ||
| G/G | 8 (16) | 11 (20) | ||
| Alleles (%) | A | 80 (80) | 83 (77) | |
| G | 20 (20) | 25 (23) | ||
| HW (p) females | 0.27 | 0.076 | ||
| HW (p) males | <0.0001 | <0.0001 | ||
|
rs1799752 ACE1 (17q23.3) c.2306-117_2306-116ins-del intron variant |
Genotypes (%) | I/I | 22(44) | 7(13) |
| I/D | 21(42) | 15(28) | ||
| D/D | 7(14) | 32(59) | ||
| Alleles (%) | I | 65(65) | 29(27) | |
| D | 35 (35) | 79(73) | ||
| HW (p) | 0.55 | 0.037 | ||
|
rs4762 AGT (1q42.2) c.620C>T p.Thr207Met |
Genotypes (%) | C/C | 35 (70) | 38 (70) |
| C/T | 14 (28) | 16 (30) | ||
| T/T | 1 (2) | 0 (0) | ||
| Alleles (%) | C | 84 (84) | 92 (85) | |
| T | 16 (16) | 16 (15) | ||
| HW (p) | 1 | 0.58 | ||
|
rs699 AGT (1q42.2) c.803T>C p.Met268Thr |
Genotypes (%) | T/T | 19 (38) | 17 (31) |
| T/C | 31 (62) | 25 (46) | ||
| C/C | 0 (0) | 12 (22) | ||
| Alleles (%) | T | 69 (69) | 59 (55) | |
| C | 31 (31) | 49 (45) | ||
| HW (p) | 0.0018 | 0.59 | ||
|
rs5186 AGTR1 (3q24) p.Met268Thr 3ʹ Prime UTR Variant |
Genotypes (%) | A/A | 27 (54) | 35 (65) |
| A/C | 21 (42) | 17 (31) | ||
| C/C | 2 (4) | 2 (4) | ||
| Alleles (%) | A | 75 (75) | 87 (81) | |
| C | 25 (25) | 21 (19) | ||
| HW (p) | 0.7 | 1 |
Notes: For each polymorphism the relative gene, chromosomal position, nucleotide variant and amino acid consequence are described.
Abbreviations: D, deletion; HWE, Hardy–Weinberg equilibrium; I, insertion.