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. 2021 Apr 27;96(17):e2172–e2183. doi: 10.1212/WNL.0000000000011827

Figure 2. Risk of Mortality and Ischemic Stroke in Relation to Quartiles of Periventricular or Confluent White Matter Hyperintensity (WMH) Volume at Baseline.

Figure 2

Associations between quartiles of periventricular or confluent WMH volume and risk of all-cause death, vascular death, nonvascular death, and ischemic stroke. Results adjusted for age, sex, intracranial volume, large infarcts on MRI, lacunes on MRI, diastolic blood pressure, systolic blood pressure, diabetes mellitus, body mass index, and smoking pack-years at baseline. The lowest quartile (<0.33 mL) was chosen as the reference category. Range second to fourth quartiles; 0.33–0.74 mL, 0.74–2.04 mL, ≥2.04 mL, respectively. Note that the scale of the y-axis may differ between outcomes. Examples of periventricular or confluent WMH from each quartile are shown in supplemental figure e-1 (available from Dryad: doi.org/10.5061/dryad.qv9s4mwd3). CI = confidence interval.