Figure 2. Flow Diagram for Determining Provisional Levels of Certainty for CTE Pathology for Research Purposes.

Specific criteria are provided in tables 1–6. These provisional criteria are not meant for clinical diagnostic purposes. Rather, they are meant for research settings by providing a description of the level of certainty (i.e., diagnostic specificity) that an individual's clinical features are due to underlying p-tau pathology meeting the current neuropathologic diagnostic criteria for CTE. CTE = chronic traumatic encephalopathy.