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. 2021 May 4;96(18):e2296–e2312. doi: 10.1212/WNL.0000000000011848

Figure 1. Baseline Plasma NfL Chain Concentrations by Clinical Phenotype.

Figure 1

(A) Original (Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects [LEFFTDS]/Advancing Research and Treatment in Frontotemporal Lobar Degeneration [ARTFL]) cohort. (B) Validation (Genetic Frontotemporal Dementia Initiative [GENFI]) cohort. Phenotypes are based on clinical diagnosis and did not rely on severity scales. Only the original cohort included clinically diagnosed prodromal disease (mild behavioral impairment [MBI] or mild cognitive impairment [MCI]). Horizontal bars represent median values. Upper and lower quartiles are delimitated by the boxes. Lowest and highest values are indicated by whiskers. bvFTD = behavioral variant frontotemporal dementia; CBS = corticobasal syndrome; FTD/ALS = frontotemporal dementia with amyotrophic lateral sclerosis; NfL = neurofilament light chain; PPA = primary progressive aphasia (nonfluent or semantic). *Compared to normal. **Compared to normal and MCI, p < 0.05.