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. 2021 May 4;96(18):e2272–e2283. doi: 10.1212/WNL.0000000000011772

Figure 4. Concomitant Pathology.

Figure 4

(A) Presence of each of the 6 vascular pathologies assessed is separately shown as a proportion of each APOE genotype and age at onset group. Whereas the interaction of age at onset with APOE genotype was not significant for any measures, effects of age at onset or presence of ε4 alleles separately are reported above the bars. (B) Distribution of nonvascular pathologies assessed in NACC by age at onset and APOE genotype. (C) Subanalysis of Lewy body disease (LBD) stage in cases with UDS 3 neuropathologic evaluation including all 5 categories (n = 809; 46%). (D) Subanalysis of TDP-43/LATE stage in cases with complete reported TDP-43 data in the amygdala, hippocampus, and neocortex (n = 368, 21%). AD = Alzheimer disease; EO = early onset; FTD = frontotemporal dementia; FTLD = frontotemporal lobar degeneration; LATE = limbic-predominant age-related TDP-43 encephalopathy; LO = late onset; MTL Scl = medial temporal lobe sclerosis; OR = odds ratio.