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. 2021 May 11;96(19):e2414–e2428. doi: 10.1212/WNL.0000000000011883

Figure 3. Effect of APOE Alleles on Cognitive Domain–Specific Composite Measures.

Figure 3

(A, C, E, and G) Model-based cognitive trajectories of (A) memory, (C) executive, (E) attention, and (G) language composite-measures z scores by APOE allele with the intercept at the time of death calculated for an 82-year-old woman with 15 years of education and autopsy findings of frequent Consortium to Establish a Registry of Alzheimer’s Disease (CERAD) neuritic plaque score and Braak neurofibrillary tangle stage V/VI and no comorbid pathologies and with adjustments for the effect of Alzheimer disease neuropathologic variables (CERAD and Braak) on the rate of cognitive decline and for comorbid pathologies (model 2). (B, D, F, and H) Difference of model-based cognitive trajectories of (B) memory, (D) executive, (F) attention, and (H) language composite-measures z scores between APOE allele groups (APOE ε2 and APOE ε4 vs APOE ε3/ε3 carriers) under model 2. Shaded areas represent the corresponding 95% confidence intervals.