Figure. Adjusted Odds Ratios (aORs) of Meaningful Expanded Disability Status Scale (EDSS) Worsening.

aORs of clinically meaningful EDSS worsening over 10 years of follow-up for patients with an average baseline ganglion cell + inner plexiform layer (GCIPL) thickness <70 µm, as compared to patients with an average baseline GCIPL thickness ≥70 µm, excluding eyes with a history of optic neuritis (ON) (comparisons of ON eyes only were performed using individual eye GCIPL thicknesses). ^aLogistic regression model with robust variance, adjusted for age at baseline optical coherence tomography (OCT), sex, race (Black or non–Black), multiple sclerosis (MS) subtype, disease duration, and patient history of ON. ^bLogistic regression model with robust variance, adjusted for age at baseline OCT, sex, race (Black or non–Black), disease duration, and patient history of ONs, restricted to patients with a diagnosis of relapsing-remitting multiple sclerosis (RRMS) at baseline. ^cLogistic regression model with robust variance, adjusted for age at baseline OCT, sex, race (Black or non–Black), MS subtype, and patient history of ON, restricted to patients with disease duration <9 years at baseline (the mean among all patients). ^dLogistic regression model with robust variance, adjusted for age at baseline OCT, sex, race (Black or non–Black), MS subtype, disease duration, and ON history, restricted to patients with an EDSS score ≤2.0 at baseline (the median among all patients). ^eLogistic regression model with robust variance, accounting for intereye correlation, adjusted for age at baseline OCT, sex, race (Black or non–Black), MS subtype, and disease duration, restricted to eyes with a history of ON. Figure made using GraphPad Prism version 8.4.2 (GraphPad Software, La Jolla, CA; graphpad.com). CI = confidence interval.