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Targeting TLRs expressed on the immune cells in the tumor microenvironment with TLR agonists. Examples of TLR agonists are shown at the top. TLRs which are expressed in human cell surface or intracellular compartments are shown in the middle. The expression of each TLR on different immune cell types is indicated by color-coded lines. Some reported low-level expressions of TLRs with unknown functional status are ignored in this figure.
