Table 1.
A summary of TLR agonists with their corresponding TLR targets.
| Target TLR | Agonist | Molecule type | References |
|---|---|---|---|
| TLR2 | Pam3Cys | Lipoproteins | [94] |
| SMP-105 | Cell wall skeleton components | [95, 96] | |
| CBLB612 | Lipopeptide | [97] | |
| TLR3 | Poly I:C | Synthetic dsRNA | [98] |
| Poly-ICLC | [99] | ||
| Poly-IC12U | [100] | ||
| IPH 3102 | [101] | ||
| ARNAX | [102, 103] | ||
| TLR4 | MPLA | Lipid | [104] |
| GLA-SE | Lipid | [105] | |
| AS04 | MPL and aluminum hydroxide | [106] | |
| OK-432 | Low virulence Streptococcus pyogenes strain | [107] | |
| TLR5 | CBLB502 | Protein | [61] |
| M-VM3 | Adenoviral vector | [74] | |
| TLR7 | Bistriazolyl | Small molecule | [108] |
| TLR8 | VTX1463 | Small molecule | [109] |
| TLR9 | MGN1703 | Polynucleotide | [61] |
| CpG-7909 | Oligonucleotide | [110] | |
| IMO2055 | [111] | ||
| dSLIM | [61] | ||
| SD-101 | [112, 113] | ||
| KSK-CpG | [88] | ||
| ODN M362 | [114] | ||
| CpG-1826 | [115] |