Figure 1.

Humoral immune responses in vaccinated rhesus macaques

(A and B) Humoral immune responses were assessed at weeks 0, 2, 4, and 6 by (A) RBD-specific binding antibody ELISA and (B) pseudovirus neutralizing antibody (NAb) assays elicited by a single immunization of 1 × 10¹¹, 5 × 10¹⁰, 1.125 × 10¹⁰, or 2 × 10⁹ vp Ad26.COV2.S (n = 5/group) or sham negative controls (n = 10). Horizontal bars reflect geometric mean responses. Dotted lines reflect assay limit of quantitation. Solid black circles indicate animals that showed no virus in bronchoalveolar lavage (BAL) and nasal swabs (NSs) following challenge; open black circles indicate animals that showed virus in NSs, but not BAL, following challenge; and open red circles indicate animals that show virus in both BAL and NS following challenge.

See also Figures S1 and S2.