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. 2021 Jun 1;184(13):3467–3473.e11. doi: 10.1016/j.cell.2021.05.040

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B cell correlates of protection in NSs

(A) Correlations of RBD- and S-specific activated memory B cell responses at days 14 and 28 following vaccination with log peak sgRNA copies/mL in NSs following challenge. Red lines reflect the best linear fit relationship between these variables. p and R values reflect two-sided Spearman rank-correlation tests. n = 25 biologically independent animals.

(B) Frequencies of RBD- and S-specific activated memory B cells in completely protected macaques (n = 13) and partially protected and non-protected macaques (n = 12). p values reflect two-sided Mann-Whitney tests.