Table 1.
Sera neutralizing antibody titres after DNA vaccine administration to BALB/c mice, Guinea pigs and New Zealand White Rabbits.
| Species | Immunization regimen | Neutralization Assay | Neutralization Titre Day 28 | Neutralization Titre Day 42 | Neutralization Titre Day 126 |
|---|---|---|---|---|---|
| BALB/c Mice | 25 μg Days 0, 14, 28 |
Micro-neutralization (SARS-CoV-2 USA-WA1/2020)-MNT100 | 20 | 40 | – |
| 100 μg Days 0, 14, 28 |
Micro-neutralization (SARS-CoV-2 USA-WA1/2020)-MNT100 | 40 | 160 | – | |
| 25 μg Days 0, 14, 28 |
GenScript® Neutralization Assay-IC50 | 14 | 82 | 23 | |
| 100 μg Days 0, 14, 28 |
GenScript® Neutralization Assay-IC50 | 71 | 168 | 91 | |
| Guinea Pigs | 25 μg Days 0, 14, 28 |
Micro-neutralization (SARS-CoV-2 USA-WA1/2020)-MNT100 | 20 | 80 | – |
| 100 μg Days 0, 14, 28 |
Micro-neutralization (SARS-CoV-2 USA-WA1/2020)-MNT100 | 40 | 320 | – | |
| 25 μg Days 0, 14, 28 |
GenScript® Neutralization Assay-IC50 | 14 | 129 | – | |
| 100 μg Days 0, 14, 28 |
GenScript® Neutralization Assay-IC50 | 21 | 371 | – | |
| New Zealand White Rabbits | 500 μg injected by NFIS Days 0, 14, 28 |
GenScript® Neutralization Assay-IC50 | 30 | 108 | – |