TABLE 3.

Top 15 most abundant miRNAs detected in mammary glands and milk EVs from different studies and species¹

	Cow		Pig		Sheep
Top 15 ranked miRNAs	Mammary glands	Milk EVs	Mammary glands	Milk EVs	Mammary glands	Milk EVs
1	Let-7a*	miR-148a*	miR-21*	Let-7a*	miR-143*	miR-148a*
2	Let-7f*	Let-7a*	miR-30a*	miR-30a*	Let-7b*	Let-7b*
3	Let-7b*	Let-7b*	Let-7a*	miR-191*	Let-7a*	Let-7a*
4	Let-7g*	miR-21*	miR-200c*	miR-21*	miR-378	miR-21*
5	miR-26a*	miR-99a	Let-7f*	miR-30d*	miR-148a*	Let-7c*
6	Let-7c*	Let-7f*	miR-191*	Let-7f*	Let-7f*	Let-7i
7	miR-21*	Let-7c*	miR-30d*	Let-7c*	miR-30a*	miR-26a
8	miR-103	miR-200c*	Let-7c*	miR-200c*	Let-7c*	Let-7f*
9	miR-29a	miR-26a*	miR-200b	Let-7g*	miR-146b	miR-125b
10	miR-30a*	miR-30d	miR-30c*	miR-320	miR-21*	miR-143*
11	miR-26b	Let-7g*	Let-7g*	miR-99a	miR-103	miR-30a*
12	miR-200c*	miR-30a*	miR-375	miR-30c*	miR-200c	miR-27a
13	miR-148a*	miR-200a	miR-24	miR-92a	miR-30d	miR-127
14	miR-1	miR-151	miR-26a	miR-425	miR-126	miR-181a
15	Let-7i	miR-423	miR-186	miR-20a	Let-7g*	Let-7g*
Reference	(73)	(48)	(74)	(46)	(75)	(18)

¹EV, extracellular vesicle; miRNA, microRNA.

*miRNAs abundant in both mammary glands and milk EVs.