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. 2021 May 28;9(5):e002432. doi: 10.1136/jitc-2021-002432

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Synergistic antitumor efficacy of in situ iPSC-DC administration and local radiotherapy (RT) against poorly immunogenic tumors. (A, B) Tumor volume curves (mean) and survival curves in AT-3 (n=7) (A) and B16 (n=6–7) (B) tumor-bearing mice in different treatment as indicated. NT, non treatment. Individual tumor volume curves are shown in online supplemental figure 1. NS not significant, *p<0.05, **p<0.01, ***p<0.001 by a log-rank test. Data shown are representative of two independent experiments. Mean±SEM. iPSC-DCs, induced pluripotent stem cell-derived dendritic cells; i.t., intratumorally.