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. 2020 Nov 16;17(3):821–828. doi: 10.1007/s12015-020-10083-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — HO-1 regulates the trafficking of normal hematopoietic stem progenitor cells (HSPCs) and leukemic cells. a HO-1 is an inhibitor of the complement cascade (ComC) and the Nlrp3 inflammasome, which are both required for optimal mobilization of HSPCs from bone marrow into peripheral blood and their migration, homing, and engraftment after transplantation. It has been found that inhibition of HO-1 promotes all these processes. b HO-1 inhibits the trafficking of leukemic cells. Therefore, enhancing the activity of HO-1 in leukemic cells by HO-1 activators may be helpful in preventing their migration and unwanted systemic spread and metastasis