Table 3.
Half-lives and t-max of ochratoxin A and aflatoxin B1 in various compartments of the kidney nephron and the liver lobule
| Kidney | ||||||
|---|---|---|---|---|---|---|
| Parameter | Mycotoxin | Capillaries | pTEC-lumen | pTEC-cells | dTEC -lumen | dTEC-cells |
| tmax (min) | OTA (10 mg/kg) | > 0.3 | > 0.3 | ND | ND | 8.4 |
| AFB1 (1.5 mg/kg) | ND | ND | > 9.2 | > 1.2 | > 1.4 | |
| t1/2 (min) | OTA (10 mg/kg) | ND | 0.4 | 2.8 | 2 | 2.3 |
| AFB1 (1.5 mg/kg) | 0.5 | 0.5 | 0.4 | 1 | 1 | |
| Liver | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | Mycotoxin | Sinusoids | Cytoplasm periportal | Cytoplasm pericentral | Nuclei periportal | Nuclei pericentral | Canaliculi | ||||||
| tmax (min) | OTA (10 mg/kg) | 1.6 | 9.3 | 1.4 | 3 | ||||||||
| AFB1 (1.5 mg/kg) | 1.3 | 1.9 | 6.9 | 2.2 | 8.2 | 1.2 | |||||||
| t1/2 (min) | OTA (10 mg/kg) | ND | ND | ND | 18 | ||||||||
| AFB1 (1.5 mg/kg) | 4 | 9 | 63 | > 5 | > 14 | 48 | |||||||
ND not-detectable