FIGURE 1.

The protocols of lamotrigine titration. Scheme of the conventional and rapid lamotrigine titration protocols. The number inside the box indicates the daily dose of lamotrigine. The conventional protocols start with a dose of 12.5 mg bid for the first and second weeks and double it to 25 mg bid in the third and fourth weeks. From the fifth week, the daily dose is increased by 50 mg every 1‐2 wk, requiring up to 8 wk to reach the maintenance dose of 200 mg/d. This conventional protocol is for patients not taking cytochrome P inducer or inhibitor. Our rapid titration protocol starts with a dose of 0.1 mg, and the next dose is escalated to 1.5‐2.5 times the previous dose every 12 h. From day 4, the same dose is given twice a day, and the daily dose is escalated to 1.5‐2 times the previous dose every day, reaching 100 mg bid on day 11. After day 11, the dose is titrated according to the clinician's decision