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. 2021 May 31;6:37. doi: 10.1038/s41525-021-00202-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Enriched biological process for noninflamed TME-specific genes expressed across tumor types. b Enriched biological process for inflamed TME-specific genes expressed across tumor types. BLCA bladder urothelial carcinoma, BRCA breast invasive carcinoma, COAD colon adenocarcinoma, LIHC liver hepatocellular carcinoma, LUAD lung adenocarcinoma, LUSC lung squamous cell carcinoma, PRAD prostate adenocarcinoma, READ rectum adenocarcinoma, SKCM skin cutaneous melanoma, STAD stomach adenocarcinoma, HNSC head and neck squamous cancer (the number below the TCGA tumor type represents the number of identified genes in each category, the gene ratio represents the ratio of differentially expressed genes in the total pathway gene sets).