Fig. 5. Reactome pathway analysis of inflamed/noninflamed-specific differently methylated regions.

a Heatmap for differently methylated probes. Red represents inflamed tumor-specific hypermethylated probes and noninflamed tumor-specific hypomethylated probes. Gray represents noninflamed tumor-specific hypermethylated probes and inflamed tumor-specific hypomethylated probes. b Enriched reactome pathways for noninflamed tumor-specific hypomethylated genes across TCGA tumor types. c Enriched reactome pathways for inflamed tumor-specific hypomethylated genes across TCGA tumor types. The number (below b and c) refers to the number of dysregulated genes (up or down) in each tumor type.