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. 2021 May 31;7:128. doi: 10.1038/s41420-021-00513-0

Fig. 7. A model for the regulation of autophagy mediated by acetyltransferase/deacetylase in B. mori and mammals.

Fig. 7

Components of the LC3/Atg8–PE ubiquitin-like system are acetylated by acetyltransferase, such as BmP300, and then translocated from the cytoplasm to the nucleus under nutrient-rich conditions. Simultaneously, high MTOR activity phosphorylates the histone deacetylases BmHDAC1/HsHDAC1, resulting in their nuclear localization. 20E, cholesterol derivatives, and starvation, which inhibit MTOR signaling, leads to the dephosphorylation of BmHDAC1/HsHDAC1, and facilitates the deacetylation of Atg proteins from LC3/Atg8–PE ubiquitin-like system, subsequently promoting their nucleo-cytoplasmic translocation and autophagy occurrence in both B. mori and mammals.