Fig. 3.

tACPA prevents inflammation and tissue injury in DSS-induced colitis mice. a A schematic overview of the DSS-induced colitis mouse model of IBD. Mice were challenged for 7 days with normal drinking water (Control) or drinking water containing 5% (w/v) DSS and were injected with PBS (No Ab), 50 mg/kg cIgG, or m-tACPA at days 3 and 5. The mice were terminated at day 7. b The inflammation score of the proximal colon was analyzed at day 7 (Supplementary Table 4). c The neutrophil count in blood was evaluated at day 7. The results are presented as the means ± SEM (n = 5–8 per group for (b) and (c)). *P < 0.05, **P < 0.01, using two-tailed Mann–Whitney statistical test (b) or unpaired two-tailed Student’s t test (c)