Fig. 4.

tACPA enhances survival and prevents tissue damage in LPS-induced sepsis mice. a A schematic overview of the LPS-induced sepsis mouse model. Mice were injected with 10 mg/kg LPS, and 30 min later, PBS (No Ab), 50 mg/kg cIgG, or hz-tACPA was administered. Dexamethasone (Dex; 10 mg/kg) was administered 1 h prior to LPS challenge. The mice were terminated at 96 h after LPS injection. b Survival was monitored for 96 h (n = 10 mice per group). Histological analysis was performed on the c spleen, d liver, e kidney, and f lung (n = 3; Supplementary Table 5). The results are presented as the means ± SEM. *P < 0.05, using one-way ANOVA with post hoc Dunn’s test for Kruskal–Wallis multiple comparisons test