Fig. 1. Identification of new recurrent TP53 variants in the human population.

A Flow chart of the strategy used to identify new germline TP53 variants in the human population. Three general population datasets and 11 country-specific datasets, the latter not included in the former, were screened for TP53 variants. The 388 missense TP53 variants were analyzed for potential constitutional variants as described in the text. B Allele frequency distribution of exonic TP53 variants in the 14 populations. rs1042522 (p.P72R) was found at high frequency, regardless of the dataset as shown at the top of the figure. C Allele frequency of TP53 variants TP53 variants found in the present study. For each variant found in four or more population datasets, the allele frequency for each dataset is shown. For five variants, the Asian populations have been circled to show the preferential origin of these variants. (A full vesrion of tis figure is available in Fig S1d).