. 2021 Apr 16;18(6):1375–1386. doi: 10.1038/s41423-021-00639-2

Table 1.

The expanding repertoire of intrahepatic immune cell populations identified by single-cell RNA sequencing

Immune cell compartment	Subpopulations identified	Reference
Kupffer cells (CD163⁺VSIG4⁺)	LIRB5⁺CD5L⁺MARCO⁺HMOX1^high immunoregulatory subset CD1C⁺FCER1A⁺ antigen-presenting subset	Aizarani et al.⁴⁶
Kupffer cells (CD68⁺)	LYZ⁺CSTA⁺CD74⁺ inflammatory macrophages CD5L⁺MARCO⁺VSIG4⁺LILRB5⁺HMOX1⁺ tolerogenic macrophages	MacParland et al.⁴²
Mononuclear phagocytes	CD163⁺MARCO⁺TIMD4^+/− Kupffer cells TREM2⁺CD9⁺ scar-associated macrophages	Ramachandran et al.^47,48
Dendritic cells	CLEC9A⁺XCR1⁺CADM1⁺ cDC1 CD1C⁺FCER1A⁺CLEC10A⁺ cDC2 LAMP3⁺CD80⁺CD83⁺CCR7⁺ activated migratory DCs	Zhang et al.¹³⁴
Natural killer cells	CD160⁺IL2RB⁺CXCR6⁺ tissue-resident NK cells CX3CR1⁺GNLY⁺GZMB⁺ classic NK cells HMGB2⁺MKI67⁺ cycling NK cells	Zhao et al.⁴⁹