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. 2021 May 31;12(6):561. doi: 10.1038/s41419-021-03844-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Protein levels of ZEB1, E-cadherin, vimentin, and N-cadherin were detected by western blot in A549, A549/GR, PC-9, and PC-9/GR cells. B STAT3 regulated the expression of ZEB1, E-cadherin, vimentin, and N-cadherin. The expression levels of the indicated proteins were examined by Western blot. C Correlation analysis between STAT3 and ZEB1 in tumor tissue. D Correlation analysis between STAT3 and ZEB1 in normal tissue. E Downregulation of ZEB1 increases the sensitivity of lung cancer cells to gefitinib. Cell viability was determined using the MTT assay. Downregulation of ZEB1 inhibits cell invasion (F) and migration (G). H ZEB1 regulated the expression of E-cadherin, vimentin, and N-cadherin. The expression levels of the indicated proteins were examined by Western blot.