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. 2021 May 31;12:3321. doi: 10.1038/s41467-021-23843-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, b Intraperitoneal (i.p.) injection of 125 mg/kg ATP restored social interaction in IP3R2 KO mice (a F_3,23 = 8.876, P = 0.0004; KO_vehicle vs. KO_ATP, P = 0.0155; b F_3,23 = 2.925, P = 0.0553; n = 7,7,6,7). c, d i.p. ATP treatment did not affect repetitive behaviors (c F_3,25 = 5.323, P = 0.0056, n = 7,7,8,7; d F_3,21 = 3.372, P = 0.0377, n = 6,6,7,6). e, f Same as (a, b) but for IP3R2 cKO mice (e F_3,21 = 13.95, P = 0.32 × 10⁻⁴; cKO_vehicle vs. cKO_ATP, P = 0.371 × 10⁻³; f F_3,21 = 0.7249, P = 0.5484; n = 6,6,6,7). g, h Same as (c, d) but for IP3R2 cKO mice (g F_3,20 = 2.761, P = 0.0689, n = 6,6,5,7; h F_3,22 = 4.761, P = 0.0105, n = 6,6,8,6). i, j Intracerebroventricular (i.c.v.) injection of ATPγS (50 µM) restored social interaction in IP3R2 cKO mice (i F_3,31 = 4.238, P = 0.0127; cKO_vehicle vs. cKO_ATPγs, P = 0.0339; j F_3,31 = 2.059, P = 0.126; n = 8,9,9,9). k, l i.c.v. ATPγS treatment did not affect repetitive behaviors (k F_3,32 = 3.942, P = 0.0168, n = 9; l F_3,29 = 8.058, P = 0.0005, n = 9,7,9,8). m, n Same as (j) but for intra-mPFC injection in IP3R2 KO mice (m F_3,23 = 3.401, P = 0.0348; KO_vehicle vs. KO_ATPγS, P = 0.0099; n F_3,23 = 0.9799, P = 0.4194; n = 6,7,6,8). o, p Intra-mPFC ATPγS treatment did not affect repetitive behaviors (o F_3,24 = 11.87, P = 0.58 × 10⁻⁴, n = 7,7,6,8; p F_3,26 = 9.106, P = 0.0003, n = 8,8,6,8). q, r Same as (m, n) but for IP3R2 cKO mice (q F_3,23 = 4.721, P = 0.0104; cKO_vehicle vs. cKO_ATPγs, P = 0.0186; r F_3,23 = 1.314, P = 0.2939; n = 6,7,6,8). s, t Same as (o, p) but for IP3R2 cKO mice (s F_3,24 = 13.62, P = 0.22 × 10⁻⁴, n = 7,7,6,8; t F_3,26 = 4.789, P = 0.0087, n = 8,8,6,8). u, v Same as (m, n) but for IP3R2 knockdown mice (u F_5,48 = 3.954, P = 0.0044; shRNA1_vehicle vs. shRNA1_ATPγs, P = 0.0108; shRNA2_vehicle vs. shRNA2_ATPγs, P = 0.0063; v F_5,48 = 0.2194, P = 0.9525; n = 9). Each data point represents an individual mouse. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. One-way ANOVA with Tukey’s (a–l, n–t, v) or Fisher’s LSD (m, u) multiple comparison post hoc test. Source data are provided as a Source data file.