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. 2021 May 31;12(6):563. doi: 10.1038/s41419-021-03843-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Expression of PBLD, tight junction (TJ) proteins, and the nuclear factor (NF)-κB signaling pathway was evaluated by immunoblotting in paired colon tissues from patients with UC (n = 6). β-actin served as an internal control. N normal colon tissue, I inflamed colon tissue. b Expression of PBLD mRNA was analyzed by quantitative reverse-transcriptase (qRT)-PCR in paired inflamed and non-inflamed colon tissue samples from UC patients (n = 9). Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) was used as an internal control. **p < 0.01. c Expression of PBLD mRNA was assessed using a published dataset (GSE75214; N = 108; normal controls, n = 11; inactive UC, n = 23; active UC, n = 74) ****p < 0.0001. d, e Levels of TNF-α and IL-6 mRNA were analyzed using qRT-PCR in paired inflamed and non-inflamed colon tissue samples from patiens with UC (n = 9). f Spearman’s correlation analysis between PBLD and TNF-α mRNA levels (r = −0.5501, p = 0.0180). g Spearman’s correlation analysis between PBLD and IL-6 mRNA levels (r = −0.6099, p = 0.0072). h, i Occludin and ZO-1 mRNA levels were analyzed using qRT-PCR in paired inflamed and non-inflamed colon tissue samples from patients with UC (n = 9). j Spearman’s correlation between PBLD and occludin mRNA levels (r = 0.4716, p = 0.0482). k Spearman’s correlation between PBLD and ZO-1 mRNA levels (r = 0.7172, p = 0.0008). l PBLD mRNA levels were analyzed using a published dataset from patients with UC who received infliximab treatment. (GSE16879; N = 24; those who responded to treatment, n = 8; nonresponders, n = 16). UCR-beforeT responder before infliximab treatment, UCR-afterT responder after infliximab treatment, UCNR-beforeT nonresponder before infliximab treatment, UCNR-afterT nonresponder after infliximab treatment.