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. 2021 May 31;11:11325. doi: 10.1038/s41598-021-90923-y

Table 1.

IGTD reduces the local heterogeneity (LH) of image representations compared with REFINED.

Neighborhood size (p) LH (IGTD) LH (REFINED) Reduction percentage by IGTD P-value
CCL 3 0.174 (0.023) 0.187 (0.026) 6.38% (7.08%) 2.05E−107
5 0.177 (0.024) 0.187 (0.027) 5.32% (6.90%) 3.37E−87
7 0.179 (0.024) 0.188 (0.027) 4.68% (6.79%) 1.96E−74
9 0.180 (0.024) 0.189 (0.027) 4.33% (6.57%) 4.65E−69
Drug 3 0.051 (0.013) 0.064 (0.017) 19.99% (4.98%) 1.50E−252
5 0.056 (0.014) 0.066 (0.017) 14.64% (4.25%) 2.82E−229
7 0.061 (0.014) 0.069 (0.017) 11.37% (3.92%) 9.87E−199
9 0.067 (0.015) 0.074 (0.018) 8.63% (3.78%) 4.56E−156

In the LH and reduction percentage columns, the number before the parenthesis is the average value obtained across CCLs or drugs, and the number in the parenthesis is the standard deviation. P-value is obtained via two-tail pairwise t-test comparing the LH between IGTD images and REFINED images across CCLs or drugs.