Table 2.
Comparison of haplotypes, genotypes, linkage groups, and the number of activating KIRs between endemic Burkitt lymphoma patients and healthy controls.
| Gene | eBL n = 104 | HC n = 104 | OR (95% CI) | p-value | |||
|---|---|---|---|---|---|---|---|
| N (%) | N (%) | ||||||
| Haplotype | |||||||
| A | 118 (56.7) | 126 (60.6) | 0.853 (0.487–1.487) | 0.673 | |||
| B | 90 (43.3) | 82 (39.4) | |||||
| KIR haplogroup and genotype frequencies | |||||||
| AA | 29 (27.9) | 36 (34.6) | 0.730 (0.400–1.308) | 0.370 | |||
| Bx | 75 (72.1) | 68 (65.4) | |||||
| AB | 60 (57.7) | 54 (51.9) | 1.263 (0.733–2.190) | 0.486 | |||
| BB | 15 (14.4) | 14 (13.5) | 1.083 (0.511–2.297) | 1.000 | |||
| KIR Bx subgroup (Linkage group) frequencies | |||||||
| C4T4 | 4 (3.8) | 0 | NA | NA | |||
| CxT4 | 10 (9.6) | 7 (6.7) | 1.474 (0.554–3.818) | 0.614 | |||
| C4Tx | 14 (13.5) | 17 (16.3) | 0.796 (0.386–1.716) | 0.698 | |||
| CxTx | 76 (73.1) | 80 (76.9) | 0.814 (0.431–1.510) | 0.631 | |||
| C4 gene-cluster | 18 (17.3) | 17 (16.3) | 1.071 (0.533–2.178) | 1.000 | |||
| T4 gene-cluster | 14 (13.5) | 7 (6.7) | 2.156 (0.807–5.495) | 0.166 | |||
| Number of activating KIRs | |||||||
| ≥ 4 | 25 (24.0) | 9 (8.7) | 3.340 (1.530–7.825) | 0.004 | |||
| < 4 | 79 (76.0) | 95 (91.3) | |||||
p ≤ 0.05 are considered statistically significant; based on the two-tailed Fisher's exact test. The haplotype A and B were obtained as follows; haplotype A = 2NAA + NAB/2n and haplotype B = 2NBB + NAB/2n. The NAA, NAB, and NBB are the numbers of AA, AB, and BB genotypes, n = total number of individuals37, 43.