Figure 4.

Combining metabolic reconstruction and structural genomics approaches for an integrated annotation of the T. maritima central metabolic network. Underlying genomics information (bottom) enabled both a metabolic reconstruction (left subpanel) and an atomic-level structure determination/modeling of all T. maritima proteins (right subpanel). Integration of these two approaches enabled detailed information to be acquired for every reaction in the network (upper subpanel); an example from the T. maritima serine degradation pathway is illustrated. Figure taken from (37).