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. 2021 May 3;296:100747. doi: 10.1016/j.jbc.2021.100747

Figure 6.

Figure 6

CWR-layered core structure of the TSR domain.A, a stereoview of C, W, and R layers in TSR2 of TSP-1. Displayed residues that are directly involved in forming the layered structure are drawn in ball and stick representation with salt bridges, and hydrogen bonds drawn as dashed lines. The big jar handle motif, which is associated with the first W layer is highlighted in pink. B, a schematic drawing of the CWR-layered structure with each layer and layer-forming residue(s) labeled. The residue Glu459 that is marked with an asterisk forms a hydrogen bond between its main chain carbonyl group and the side chain of Arg442 in the R1 layer. The three antiparallel strands are drawn in lines schematically with arrowheads indicating their polarities. The three bulges associated with the rippled strand A and the big jar handle are also shown. Figure taken from (40). TSR, thrombospondin type 1 repeat.