Table 3.
Protein | Normal weight (18.5 to < 25 kg/m2) | Overweight/ obesity (≥ 25 kg/m2) | p-value interact | p-value interact* | ||||
---|---|---|---|---|---|---|---|---|
Coef | 95% CI | p-value | Coef | 95% CI | p-value | |||
CCL3 | 0.34 | 0.23 to 0.46 | < 0.001 | 0.60 | 0.43 to 0.77 | < 0.001 | 0.159 | 0.041 |
CCL20 | 0.09 | − 0.03 to 0.20 | 0.232 | 0.37 | 0.19 to 0.55 | < 0.001 | 0.120 | 0.023 |
CDCP1 | 0.27 | 0.16 to 0.38 | < 0.001 | 0.88 | 0.71 to 1.05 | < 0.001 | 0.005 | < 0.001 |
DNER | − 0.19 | − 0.31 to − 0.08 | 0.007 | − 0.30 | − 0.47 to − 0.12 | 0.002 | 0.161 | 0.044 |
FGF21 | 0.30 | 0.19 to 0.42 | < 0.001 | 0.74 | 0.58 to 0.91 | < 0.001 | 0.111 | 0.019 |
FGF23 | 0.07 | − 0.05 to 0.19 | 0.343 | 0.56 | 0.39 to 0.72 | < 0.001 | 0.030 | 0.003 |
HGF | 0.12 | 0.01 to 0.23 | 0.082 | 0.72 | 0.57 to 0.87 | < 0.001 | < 0.001 | < 0.001 |
IL6 | 0.50 | 0.39 to 0.61 | < 0.001 | 0.86 | 0.72 to 1.00 | < 0.001 | < 0.001 | < 0.001 |
IL18 | 0.14 | 0.02 to 0.26 | 0.057 | 0.46 | 0.30 to 0.63 | < 0.001 | 0.157 | 0.035 |
LAPTGFbeta1 | − 0.03 | − 0.14 to 0.09 | 0.733 | 0.33 | 0.15 to 0.50 | 0.001 | 0.032 | 0.004 |
MCP1 | − 0.10 | − 0.21 to 0.01 | 0.153 | 0.36 | 0.20 to 0.53 | < 0.001 | 0.030 | 0.003 |
MCP4 | − 0.08 | − 0.20 to 0.04 | 0.255 | 0.27 | 0.11 to 0.44 | 0.003 | 0.005 | < 0.001 |
OSM | 0.02 | − 0.10 to 0.13 | 0.843 | 0.35 | 0.18 to 0.52 | < 0.001 | 0.111 | 0.018 |
TNFSF14 | 0.15 | 0.04 to 0.26 | 0.034 | 0.38 | 0.21 to 0.54 | < 0.001 | 0.121 | 0.025 |
Stratified analyses in BMI categories from linear regression of transformed protein levels adjusted for sex, smoking, e-cigarette use, snuff use, and age at follow-up.
The table includes all proteins with unadjusted p-value for the interaction term %BF#BMI_category of < 0.05.
p-values at 0.05 FDR.
*p-value for the interaction term without FDR correction.