Table 4.
Protein | Females | Males | p-value interact | p-value interact* | ||||
---|---|---|---|---|---|---|---|---|
Coef | 95% CI | p-value | Coef | 95% | p-value | |||
4EBP1 | 0.08 | 0.05 to 0.12 | < 0.001 | 0.04 | 0.02 to 0.06 | < 0.001 | 0.113 | 0.040 |
ADA | 0.09 | 0.06 to 0.13 | < 0.001 | 0.03 | 0.01 to 0.04 | 0.003 | 0.008 | 0.001 |
AXIN1 | 0.09 | 0.05 to 0.13 | < 0.001 | 0.04 | 0.02 to 0.06 | < 0.001 | 0.098 | 0.034 |
CCL3 | 0.18 | 0.14 to 0.21 | < 0.001 | 0.09 | 0.07 to 0.11 | < 0.001 | 0.002 | < 0.001 |
CCL19 | 0.12 | 0.08 to 0.16 | < 0.001 | 0.05 | 0.03 to 0.07 | < 0.001 | 0.008 | 0.001 |
CCL28 | − 0.09 | − 0.13 to − 0.05 | < 0.001 | − 0.03 | − 0.05 to − 0.01 | 0.007 | 0.017 | 0.004 |
CD5 | 0.09 | 0.05 to 0.12 | < 0.001 | 0.03 | 0.01 to 0.05 | 0.004 | 0.013 | 0.003 |
CDCP1 | 0.20 | 0.17 to 0.24 | < 0.001 | 0.13 | 0.11 to 0.15 | < 0.001 | 0.007 | 0.001 |
DNER | − 0.07 | − 0.11 to − 0.03 | < 0.001 | − 0.03 | − 0.05 to − 0.01 | 0.015 | 0.098 | 0.034 |
HGF | 0.16 | 0.13 to 0.20 | < 0.001 | 0.09 | 0.07 to 0.10 | < 0.001 | 0.002 | < 0.001 |
IL6 | 0.26 | 0.22 to 0.29 | < 0.001 | 0.11 | 0.08 to 0.13 | < 0.001 | < 0.001 | < 0.001 |
IL12B | 0.11 | 0.07 to 0.14 | < 0.001 | 0.04 | 0.01 to 0.06 | 0.002 | 0.013 | 0.002 |
IL18 | 0.12 | 0.09 to 0.15 | < 0.001 | 0.07 | 0.04 to 0.09 | < 0.001 | 0.029 | 0.007 |
MCP1 | 0.11 | 0.08 to 0.15 | < 0.001 | 0.03 | 0.01 to 0.05 | 0.001 | 0.002 | < 0.001 |
MCP4 | 0.09 | 0.05 to 0.13 | < 0.001 | 0.03 | 0.01 to 0.05 | 0.002 | 0.037 | 0.010 |
SCF | − 0.01 | − 0.05 to 0.03 | 0.544 | − 0.08 | − 0.10 to − 0.06 | < 0.001 | 0.013 | 0.002 |
TNFRSF9 | 0.06 | 0.02 to 0.10 | 0.004 | 0.01 | 0.00 to 0.03 | 0.153 | 0.098 | 0.031 |
TNFSF14 | 0.13 | 0.09 to 0.16 | < 0.001 | 0.06 | 0.04 to 0.08 | < 0.001 | 0.008 | 0.001 |
TRAIL | 0.11 | 0.07 to 0.14 | < 0.001 | 0.06 | 0.04 to 0.08 | < 0.001 | 0.052 | 0.015 |
VEGFA | 0.15 | 0.12 to 0.19 | < 0.001 | 0.08 | 0.05 to 0.11 | < 0.001 | 0.013 | 0.003 |
Stratified analyses in men and women from linear regression of transformed protein levels adjusted for smoking, e-cigarette use, snuff use, and age at follow-up.
The table includes all proteins with unadjusted p-value for the interaction term %BF#sex of < 0.05.
p-values at 0.05 FDR.
*p-value for the interaction term without FDR correction.