Table 5.
Protein | Normal weight (18.5 to < 25 kg/m2) | Overweight/obesity (≥ 25 kg/m2) | p-value interact | p-value interact* | ||||
---|---|---|---|---|---|---|---|---|
Coef | 95% CI | p-value | Coef | 95% CI | p-value | |||
CCL3 | 0.15 | 0.10 to 0.21 | < 0.001 | 0.10 | 0.07 to 0.12 | < 0.001 | 0.201 | 0.018 |
CCL11 | − 0.12 | − 0.17 to − 0.07 | < 0.001 | − 0.03 | − 0.05 to 0.00 | 0.057 | 0.020 | 0.001 |
CCL23 | − 0.04 | − 0.10 to 0.02 | 0.331 | 0.03 | 0.01 to 0.06 | 0.010 | 0.208 | 0.023 |
IL6 | 0.18 | 0.12 to 0.24 | < 0.001 | 0.13 | 0.09 to 0.17 | < 0.001 | 0.068 | 0.005 |
LIFR | − 0.16 | − 0.21 to − 0.10 | < 0.001 | − 0.02 | − 0.05 to 0.00 | 0.113 | < 0.001 | < 0.001 |
MCP1 | − 0.04 | − 0.09 to 0.01 | 0.299 | 0.06 | 0.04 to 0.09 | < 0.001 | 0.045 | 0.002 |
SCF | − 0.03 | − 0.09 to 0.02 | 0.366 | − 0.06 | − 0.09 to − 0.03 | < 0.001 | 0.305 | 0.039 |
Stratified analyses in BMI categories from linear regression of transformed protein levels adjusted for sex, smoking, e-cigarette use, snuff use, and age at follow-up.
The table includes all proteins with unadjusted p-value for the interaction term VFR#BMI_category of < 0.05.
p-values at 0.05 FDR.
*p-value for the interaction term without FDR correction.