Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 18;12:665521. doi: 10.3389/fendo.2021.665521

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Creusot, Garoche, Grimaldi, Boulahtouf, Chiavarina, Bourguet and Balaguer

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Structural analysis of zfPXR selectivity. A zfPXR LBD model was generated and superimposed on the crystallographic structures of hPXR LBD in complex with the reference agonist SR12813 (A) and clotrimazole (B). The ligands and side chains of hPXR residues are shown as orange sticks, while zfPXR residues are colored in green. The conserved π-trap residues in hPXR (W299, Y306) and zfPXR (W295, Y302) are displayed in light orange and light green, respectively. For clarity, only residue differences at key positions are shown.