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. 2021 May 18;11:665037. doi: 10.3389/fonc.2021.665037

Figure 3.

Figure 3

(A) Correlation between soluble mediator levels and laboratory parameters of healthy subjects (CTRL, n = 17) and patients with essential thrombocythemia (ET, n = 28), polycythemia vera (PV, n = 19), and primary myelofibrosis (PMF, n = 16). The Spearman coefficient (r-value) was represented by a color gradient that ranged from close to 1 (dark blue) to −1 (dark red); white indicates no correlation. The correlations depicted in this figure were significant when p <0.05. HCT, hematocrit; HGB, hemoglobin concentration; PLT, platelet count; RBC, red blood cell count; WBC, white blood cell count. (B) Association between driver mutation status and IL-6Ra, CXCL12, and M-CSF levels in bone marrow plasma from patients with ET. JAK2V617+ (n = 13 ET patients positive for JAK2V617F mutation). JAK2V617F- (n = 5; ET patients negative for JAK2V617F mutation). CALR+ (n = 7; patients positive for calreticulin mutation). DN (n = 3; double negative for CALR and JAK2V617 patients). Statistical difference when p <0.05, Mann–Whitney test.