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. 2021 May 18;12:652488. doi: 10.3389/fimmu.2021.652488

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Copyright © 2021 Janicova, Haag, Xu, Garza, Dunay, Neunaber, Nowak, Cavalli, Marzi, Sturm and Relja

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of acute alcohol intoxication on inflammasome activation in monocytes and their adhesive capacity upon LPS and ATP or only LPS stimulation ex vivo. Experimental design and representative gating strategy for caspase-1 is shown in (A, B). Percentage expression of caspase-1 in CD14⁺ monocytes (C) and their adhesive capacity (D) following ex vivo LPS stimulation was determined in blood of healthy volunteers (n=22) before (T0) and 2 (T2), 4 (T4), 6 (T6), 24 (T24) and 48 (T48) hours after starting the alcohol consumption. Data are presented as mean ± standard error of the mean. *p < 0.05 vs. T0 and indicated.