Fig. 4. Selective 1,1-difluoroallylation of natural products and pharmaceuticals.

Standard reaction conditions: 1a (1.2 equiv), 2 (1 equiv), NaH (1.5 equiv) in DMF (0.2 M), the reaction mixture was performed at 23 °C under argon atmosphere for 30 min, isolated yield, the α/γ regioselectivity was determined by crude ¹⁹F NMR analyses. ^†Cs₂CO₃ (0.5 equiv) and toluene (0.1 M) were used as base and solvent, the reaction was performed at 50 °C under air atmosphere for 18 h.