Skip to main content
. 2021 Jan 25;28(5):1658–1668. doi: 10.1038/s41418-020-00692-w

Fig. 2. Bcl-XL plays an important role in venetoclax drug resistance in CLL.

Fig. 2

A,B CLL cells were cultured for 24 h on 3T3 or 3T40L. After detachment, cells were treated with a titration of ABT-199 (0–2500 nM) for 24 h with or without inhibition of Bcl-XL (A-1331852). For inhibition of Bcl-XL, a titration of 0-30-117-468-1875-7500 nM A-1331852 was used. Viability (A) was measured using flow cytometry using DiOC6 and TO-PRO3 viability stainings (Thermo Scientific). Specific apoptosis (B) was calculated. Averaged data of 4 CLL samples are shown. Bars represent the mean ± SEM, *p < 0.05, **p < 0.01 (paired t-test (3T40L versus 3T40L + A-1331852)).