Table 2.
Prostate cancer risk alleles of the HOXB locus.
| Pairwise LD | Variant | chr:position | ICPCG | PLCO | NFPCS | Combined studies | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | P | Carrier freq. | ||||||||||
| OR | P | OR | P | OR | P | Control | Case | |||||
|
rs190859858_C | 17:45416600 | 4.2 | 2.0E−04 | 2.0 | 0.036 | 4.6 | 0.019 | 3.0 | 1.5E−06 | 0.005 | 0.014 |
| rs559798379_C | 17:45574038 | 4.1 | 1.0E−04 | 2.3 | 3.1E−03 | 3.4 | 0.039 | 3.0 | 8.8E−08 | 0.006 | 0.017 | |
| rs369461501_T | 17:45615944 | 4.2 | 1.6E−04 | 2.1 | 0.019 | 4.3 | 0.027 | 3.1 | 7.8E−07 | 0.005 | 0.014 | |
| rs149063695_G | 17:45658911 | 4.8 | 9.6E−05 | 2.2 | 0.013 | 4.2 | 0.029 | 3.2 | 2.9E−07 | 0.005 | 0.015 | |
| rs568360281_T | 17:46054408 | 10.4 | 8.5E−05 | 3.3 | 6.7E−03 | 6.2 | 0.018 | 5.7 | 5.0E−08 | 0.002 | 0.012 | |
| rs569885052_T | 17:46185108 | 8.3 | 5.3E−05 | 6.0 | 3.3E−03 | 8.8 | 0.041 | 7.5 | 5.3E−08 | 0.002 | 0.011 | |
| rs559612720_C | 17:46238735 | 13.2 | 1.6E−05 | 4.6 | 1.5E−03 | 11.4 | 0.021 | 8.1 | 2.1E−09 | 0.002 | 0.014 | |
| rs537343973_A | 17:46711519 | 5.1 | 3.4E-08 | 1.6 | 0.046 | 2.5 | 0.020 | 2.6 | 1.0E−09 | 0.010 | 0.026 | |
| rs549975035_T | 17:46732251 | 5.1 | 3.4E-08 | 1.6 | 0.046 | 2.3 | 0.039 | 2.7 | 1.2E−09 | 0.010 | 0.025 | |
| rs576161544_G | 17:46763849 | 5.4 | 4.5E-08 | 1.9 | 8.5E-03 | 2.9 | 0.011 | 3.1 | 5.0E−11 | 0.008 | 0.025 | |
| rs138213197_T | 17:46805705 | 6.9 | 2.2E−07 | 3.4 | 2.9E−03 | 8.7 | 4.2E−03 | 5.6 | 2.4E−11 | 0.003 | 0.018 | |
| rs138467395_C | 17:46860777 | 3.4 | 1.2E−06 | 1.7 | 0.049 | 2.6 | 0.026 | 2.5 | 2.1E−08 | 0.009 | 0.023 | |
Linkage disequilibrium (LD) is depicted for controls (greyscale, R2 = 1 in black and R2 = 0 in white). Results for each study population are presented for models regressing cancer status against a given variant with adjustment for the first ten principal components of genetic ancestry. Bold font designates sentinels best detecting independent risk signals. The HOXB13 G84E variant is rs138213197.