Table 1.
Compound | Mean difference of mCit-LC3 (%) | SD | SSMD |
---|---|---|---|
P05E07 | −34.4 | ±6.0 | −3.25 |
P02E06 | −28.8 | ±1.3 | −12.58 |
P04C02 | −27.4 | ±5.6 | −2.75 |
P01F03 | −22.0 | ±11.2 | −1.11 |
P05C06 | −19.9 | ±4.6 | −2.43 |
P01G08 | −18.1 | ±8.1 | −1.26 |
P03F08 | −17.7 | ±3.3 | −3.04 |
P02B03 | −17.3 | ±6.0 | −1.62 |
SD standard deviation SSMD strictly standardized mean difference.
In total, eight compounds causing equal to or greater than 15% LC3 degradation at a fairly moderate and higher effect (│SSMD score│ ≥1) at 10 µM after 6 h of treatment were classified as potential inducers of autophagy.
Data show mean difference ± SD (% of control) of mCitrine-LC3 decrease upon full medium monitored by flow cytometry.