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. 2021 May 31;4:642. doi: 10.1038/s42003-021-02179-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Manhattan plots of the EWAS of chronological age. The coordinates are estimated based on the alignment of Mammalian array probes to killer whale (GCF_000331955.2_Oorc_1.1) genome assembly. The direction of associations with P < 0.0001 (red dotted line) is highlighted by red (hypermethylated) and blue (hypomethylated) colors. Top 10 CpGs were labeled by the neighboring genes. Venn diagrams representing the overlap of aging-associated CpGs in skin (b) and blood (c) of these species. The conserved DNAm aging loci in blood and skin samples were marked by neighboring gene symbol. This analysis was limited to top CpGs that were selected at P < 0.0001 and further filtering based on z score of association with chronological age for up to 500 in a positive or negative direction. The number of selected CpGs: beluga blood, 1000; beluga skin, 639; bottlenose dolphin blood, 1000; bottlenose dolphin skin, 68; Pacific white-sided dolphin blood, 490; Pacific white-sided dolphin skin, 564; killer whale blood, 935; killer whale skin, 665. d Location of top CpGs in each species relative to the closest transcriptional start site. e Box plot represents 25th and 75th percent quartiles, the line represents the median, and whiskers are 90% of aging association stratified by CpG island status in killer whale genome. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.