Table 3.
The associations between serum bilirubin level and different types of UGT1A1 mutation and genotypes adjusted by age, gender, and feeding practice: Linear regression analysis (N = 59a)
| Genotypes | TBIL | IBIL | ||
|---|---|---|---|---|
| ORadjb (95%CI) | P | ORadjb (95%CI) | P | |
| TATA box | ||||
| TA6/TA6 | 0.00 | 0.57 | 0.00 | 0.58 |
| TA6/TA7 | 30.0(−73.1–133.2) | 27.6(−70.4–125.5) | ||
| c.211 G > A | ||||
| G/G | 0.00 | 0.019 | 0.00 | 0.02 |
| G/A-A/A | 78.2(14.7–141.8) | 73.3(12.8–133.7) | ||
| c.1091 C > T | ||||
| C/C | 0.00 | 0.16 | 0.00 | 0.14 |
| C/T | 103.1(−39.8–245.9) | 103.6(−31.7–238.9) | ||
| Haplotypec (Frequency) | ||||
| TA6GC(75.85%) | 0.00 | 0.00 | ||
| TA6AC(16.53%) | 84.0(23.2–144.8) | 0.0092 | 79.0(21.4–136.6) | 0.0097 |
| TA7GC(5.08%) | 70.4(−26.8–167.7) | 0.16 | 65.6(−26.6–157.9) | 0.17 |
| TA6GT(2.12%) | 107.9(93.7–122.1) | < 0.0001 | 107.01(93.6–120.4) | < 0.0001 |
| TA6AT(0.42%) | 149.9(147.3–152.6) | < 0.0001 | 152.4(150.0–154.8) | < 0.0001 |
a Ten cases with the feeding practice unknown were not taken into the regression analysis
bAdjusted for age, gender, and feeding practice
cpolymorphisms are in order of: rs8175347-rs4148323-rs34946978