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. 2021 Apr 20;40(11):e102277. doi: 10.15252/embj.2019102277

Figure 6. The corresponding SUD:Paip1 interaction exists in SARS‐CoV‐2.

Figure 6

  1. Sequence alignment of SUD between SARS‐CoV (GenBank: AY291315) and SARS‐CoV‐2 (GenBank: MN908947). Domains Mac2 (SUD‐N), Mac3 (SUD‐M), and DPUP (SUD‐C) range from K389 to L526, G527 to S652, and K653 to S720, respectively. The first 16 residues of Mac2 are boxed in blue. This figure was generated by using the ESPript server (http://espript.ibcp.fr/ESPript/ESPript/).
  2. SARS‐CoV‐2 SUD (SARS2‐SUD) interacts with Paip1 in HEK‐293 cells as demonstrated by the split‐YFP assay.
  3. SARS2‐Mac2 binds to Paip1. SARS2‐Mac2 but not Δ16‐SARS2‐Mac2 interacts with Paip1M.
  4. MERS‐CoV SUD‐MC (Mac3–DPUP) or XMC (Mac1–Mac3–DPUP) do not bind to Paip1.

Data information: Scale bars represent 50 µm.