Table 1. Local adverse reactions, systemic reactions, and antipyretic use after the second dose according to sex and age groups.
| Variables | Total (n = 265) | Sex | P value | Age group | P for trend | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Female (n = 170) | Male (n = 95) | 20s (n = 86) | 30s (n = 92) | 40s (n = 37) | 50s (n = 23) | 60s (n = 27) | |||||||
| Adverse reactions | |||||||||||||
| Any | 236 (89.1) | 162 (95.3) | 74 (77.9) | < 0.001 | 78 (90.7) | 84 (91.3) | 32 (86.5) | 21 (91.3) | 21 (77.8) | 0.108 | |||
| Local reactions | |||||||||||||
| Pain | 212 (80.0) | 149 (87.8) | 63 (66.3) | < 0.001 | 75 (87.2) | 75 (81.5) | 29 (78.4) | 15 (65.2) | 18 (66.7) | 0.003 | |||
| Itch | 25 (9.4) | 19 (11.2) | 6 (6.3) | 0.281 | 13 (15.1) | 7 (7.6) | 4 (10.8) | 0 (0.0) | 1 (3.7) | 0.028 | |||
| Redness | 26 (9.8) | 22 (12.9) | 4 (4.2) | 0.038 | 8 (9.3) | 11 (12.0) | 3 (8.1) | 1 (4.3) | 3 (11.1) | 0.790 | |||
| Swelling | 27 (10.2) | 25 (14.7) | 2 (2.1) | 0.002 | 10 (11.6) | 7 (7.6) | 2 (5.4) | 4 (17.4) | 4 (14.8) | 0.521 | |||
| Systemic reactions | |||||||||||||
| Fever | 85 (32.1) | 64 (37.6) | 21 (22.1) | 0.014 | 38 (44.2) | 36 (39.1) | 6 (16.2) | 2 (8.7) | 3 (11.1) | < 0.001 | |||
| Chills | 117 (44.2) | 85 (50.0) | 32 (33.7) | 0.015 | 44 (51.2) | 50 (54.3) | 13 (35.1) | 6 (26.1) | 4 (14.8) | < 0.001 | |||
| Muscle ache | 183 (69.1) | 127 (74.7) | 56 (58.9) | 0.012 | 61 (70.9) | 74 (80.4) | 21 (56.8) | 13 (56.5) | 14 (51.9) | 0.007 | |||
| Joint pain | 81 (30.6) | 61 (35.9) | 20 (21.1) | 0.018 | 29 (33.7) | 30 (32.6) | 9 (24.3) | 7 (30.4) | 6 (22.2) | 0.218 | |||
| Headache | 129 (48.7) | 93 (54.7) | 36 (37.9) | 0.013 | 48 (55.8) | 49 (53.3) | 18 (48.6) | 7 (30.4) | 7 (25.9) | 0.002 | |||
| Dizziness | 69 (26.0) | 55 (32.4) | 14 (14.7) | 0.003 | 31 (36.0) | 26 (28.3) | 7 (18.9) | 3 (13.0) | 2 (7.4) | < 0.001 | |||
| Confused mentality | 16 (6.0) | 13 (7.6) | 3 (3.2) | 0.229 | 9 (10.5) | 3 (3.3) | 2 (5.4) | 0 (0.0) | 2 (7.4) | 0.251 | |||
| Anxiety | 15 (5.7) | 13 (7.6) | 2 (2.1) | 0.111 | 9 (10.5) | 3 (3.3) | 2 (5.4) | 0 (0.0) | 1 (3.7) | 0.081 | |||
| Dyspepsia | 45 (17.0) | 31 (18.2) | 14 (14.7) | 0.578 | 19 (22.1) | 15 (16.3) | 6 (16.2) | 1 (4.3) | 4 (14.8) | 0.118 | |||
| Abdominal pain | 28 (10.6) | 21 (12.4) | 7 (7.4) | 0.290 | 13 (15.1) | 8 (8.7) | 3 (8.1) | 1 (4.3) | 3 (11.1) | 0.259 | |||
| Vomiting | 23 (8.7) | 17 (10.0) | 6 (6.3) | 0.427 | 13 (15.1) | 6 (6.5) | 3 (8.1) | 0 (0.0) | 1 (3.7) | 0.019 | |||
| Diarrhea | 33 (12.5) | 21 (12.4) | 12 (12.6) | > 0.99 | 15 (17.4) | 15 (16.3) | 2 (5.4) | 0 (0.0) | 1 (3.7) | 0.004 | |||
| Fatigue | 174 (65.7) | 117 (68.8) | 57 (60.0) | 0.188 | 60 (69.8) | 71 (77.2) | 22 (59.5) | 10 (43.5) | 11 (40.7) | < 0.001 | |||
| Palpitation | 24 (9.1) | 19 (11.2) | 5 (5.3) | 0.166 | 12 (14.0) | 8 (8.7) | 2 (5.4) | 1 (4.3) | 1 (3.7) | 0.044 | |||
| Hypertension | 14 (5.3) | 11 (6.5) | 3 (3.2) | 0.384 | 9 (10.5) | 3 (3.3) | 1 (2.7) | 0 (0.0) | 1 (3.7) | 0.051 | |||
| Hypotension | 14 (5.3) | 11 (6.5) | 3 (3.2) | 0.384 | 9 (10.5) | 3 (3.3) | 1 (2.7) | 0 (0.0) | 1 (3.7) | 0.051 | |||
| Paralysis | 14 (5.3) | 11 (6.5) | 3 (3.2) | 0.384 | 9 (10.5) | 3 (3.3) | 1 (2.7) | 0 (0.0) | 1 (3.7) | 0.051 | |||
| Paraesthesia | 15 (5.7) | 11 (6.5) | 3 (3.2) | 0.627 | 9 (10.5) | 3 (3.3) | 1 (2.7) | 0 (0.0) | 1 (3.7) | 0.051 | |||
| Nasal obstruction | 33 (12.5) | 22 (12.9) | 11 (11.6) | 0.898 | 16 (18.6) | 11 (12.0) | 3 (8.1) | 1 (4.3) | 2 (7.4) | 0.033 | |||
| Angioedema | 16 (6.0) | 11 (6.5) | 5 (5.3) | 0.899 | 10 (11.6) | 4 (4.3) | 1 (2.7) | 0 (0.0) | 1 (3.7) | 0.031 | |||
| Tongue edema | 15 (5.7) | 12 (7.1) | 3 (3.2) | 0.298 | 9 (10.5) | 3 (3.3) | 2 (5.4) | 0 (0.0) | 1 (3.7) | 0.081 | |||
| Parageusia | 11 (4.2) | 7 (4.1) | 4 (4.2) | > 0.99 | 2 (2.3) | 4 (4.3) | 3 (8.1) | 1 (4.3) | 1 (3.7) | 0.507 | |||
| Foreign body sense in throat | 37 (14.0) | 21 (12.4) | 16 (16.8) | 0.409 | 16 (18.6) | 10 (10.9) | 4 (10.8) | 2 (8.7) | 5 (18.5) | 0.591 | |||
| Throat swelling and tightness | 30 (11.3) | 18 (10.6) | 12 (12.6) | 0.763 | 13 (15.1) | 7 (7.6) | 3 (8.1) | 4 (17.4) | 3 (11.1) | 0.782 | |||
| Hoarseness | 11 (4.2) | 8 (4.7) | 3 (3.2) | 0.776 | 6 (7.0) | 3 (3.3) | 1 (2.7) | 0 (0.0) | 1 (3.7) | 0.931 | |||
| Odynophagia | 18 (6.8) | 13 (7.6) | 5 (5.3) | 0.628 | 9 (10.5) | 3 (3.3) | 3 (8.1) | 2 (8.7) | 1 (3.7) | 0.413 | |||
| Wheezing | 8 (3.0) | 4 (2.4) | 4 (4.2) | 0.636 | 4 (4.7) | 2 (2.2) | 1 (2.7) | 0 (0.0) | 1 (3.7) | 0.509 | |||
| Chest discomfort | 8 (3.0) | 4 (2.4) | 4 (4.2) | 0.636 | 4 (4.7) | 2 (2.2) | 1 (2.7) | 0 (0.0) | 1 (3.7) | 0.509 | |||
| Urticaria | 5 (1.9) | 3 (1.8) | 2 (2.1) | > 0.99 | 2 (2.3) | 2 (2.2) | 1 (2.7) | 0 (0.0) | 0 (0.0) | 0.384 | |||
| Skin rash | 10 (3.8) | 7 (4.1) | 3 (3.2) | 0.954 | 4 (4.7) | 3 (3.3) | 2 (5.4) | 0 (0.0) | 1 (3.7) | 0.625 | |||
| Use of antipyretics | 177 (66.8) | 124 (72.9) | 53 (55.8) | 0.007 | 60 (69.8) | 69 (75.0) | 20 (54.1) | 16 (69.6) | 12 (44.4) | 0.862 | |||
Data are presented as number (%).