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. 2021 May 18;12:644225. doi: 10.3389/fphar.2021.644225

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Copyright © 2021 Liu, Yan, Yang, Qin, Chen, Li, Si, Li and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of APN on sepsis-induced myocardial injury. (A) HE staining of myocardial tissue at 400×. (B) Bcl2 was downregulated and Bax and cleaved caspase-3 were upregulated in myocardial tissues of septic mice, but these effects were attenuated by APN. (C–E) Quantification of Bax, Bcl2, and cleaved caspase-3 expression. (F) Cx43 was upregulated in myocardial tissue of septic mice, and this effect was changed by APN. (G) Quantification of Cx43 expression. (H) Immunohistochemical staining showed the expression of Cx43 in myocardial tissue. Scale bar: 25 μm. The brown immunostaining represents Cx43. (*p < 0.05, **p < 0.01 vs. control; ^# p < 0.05, ^## p < 0.01 vs. the LPS group. The data are shown as the means ± SEs (n = 6)).