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. 2021 Apr 28;6(2):64. doi: 10.3390/tropicalmed6020064

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© 2021 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Protective immunity in cholera. Immune protection after infection or oral immunization is mediated mainly, if not exclusively, by locally produced SIgA antibodies that are directed against the cell surface LPS O antigen (predominantly against the A epitope defining the O1 serogroup, but also against the serotype-specific epitopes B (Ogawa) and C (Inaba) and the cholera toxin (mainly against the B subunit pentamer), and which inhibit bacterial colonization and toxin binding, respectively.