Table 4.
Sensitivity, specificity, positive predictive value, and negative predictive value of different AFP response assessments for predicting overall survival, progression free survival and objective response rate
| Variables | 50-10 rule at week 4 & 12 | 50% reduction at week 4 | 10% reduction at week 4 | 10% reduction at week 12 |
|---|---|---|---|---|
| OS | ||||
| Sensitivity | 66.0 | 28.0 | 40.0 | 64.0 |
| Specificity | 70.0 | 87.5 | 65.0 | 67.5 |
| PPV | 72.7 | 73.4 | 58.8 | 71.7 |
| NPV | 61.4 | 49.3 | 46.4 | 60.9 |
| PFS | ||||
| Sensitivity | 76.9 | 30.8 | 50.0 | 76.9 |
| Specificity | 67.2 | 82.8 | 62.5 | 59.4 |
| PPV | 45.5 | 42.1 | 29.5 | 43.5 |
| NPV | 87.0 | 74.6 | 79.6 | 86.4 |
| ORR | ||||
| Sensitivity | 90.5 | 42.9 | 71.4 | 85.7 |
| Specificity | 72.5 | 85.5 | 62.3 | 60.9 |
| PPV | 40.9 | 47.4 | 44.1 | 41.3 |
| NPV | 95.5 | 83.1 | 89.3 | 93.5 |
Abbreviations: NPV, negative predictive value; ORR, objective response rate; OS, overall survival; PFS, progression free survival; PPV, positive predictive value.