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Schematic of the mechanisms of signaling pathways of Abi. Declined synthesis of the androgens in prostate cancer adrenal glands, and related tissue because of inhibiting the enzymes CYP17, 20 lyase and 17α hydroxylase irreversibly by ABI. ABI: abiraterone; CYP17A1: CYP450 17α-hydroxy/17,20-lyase; AR: androgen receptor; TSPYL: testis-specific-encoding-like; DHT: Dihydrotestosterone; AKR1C3: Aldo-Keto Reductase Family 1 Member C3.
