Figure 6.

Improved inhibition of Cervical cancer growth by combination treatment. (A and D) show the effect of 0.2 mg/kg Minnelide, 20 mg/kg Carboplatin, and a combination of both treatments on subcutaneous tumor volume over the course of experiment. Treatment started 7 days after tumor cell implantation and continued until day 42. (A), CaSki, (D), ME-180. (B and E) show the effect of 0.2 mg/kg Minnelide, 20 mg/kg Carboplatin, and a combination of both treatments on tumor weight at the end of the experiment. Each dot in the scatter plot represents one mouse. (B), CaSki, (E), ME-180. (C) shows the effect of 0.2 mg/kg Minnelide, 20 mg/kg Carboplatin, and a combination of both treatments on the survival of athymic mice bearing subcutaneous tumors (CaSki) from an independent experiment. Statistically significant differences are denoted by asterisks. Group comparisons are indicated by lines. ‘#’ in (A) shows comparison between Minnelide and combination group which was statistically significant.